期刊
NATURE REVIEWS IMMUNOLOGY
卷 19, 期 10, 页码 599-613出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41577-019-0194-8
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资金
- Royal Society
- Wellcome Trust Sir Henry Dale Fellowship [105644/Z/14/Z]
- National Institutes of Health [R01AI143842, R01AI123368, R01AI145989, U01AI095608]
- NIAID Mucosal Immunology Studies Team (MIST)
- Crohn's and Colitis Foundation
- Searle Scholars Program
- American Asthma Foundation Scholar Award
- Center for Advanced Digestive Care (CADC)
- Wade F.B. Thompson/Cancer Research Institute CLIP Investigator grant
- Meyer Cancer Center Collaborative Research Initiative
- Burroughs Wellcome Fund
- Roberts Institute for Research in IBD
Innate lymphoid cells (ILCs) are enriched at barrier surfaces of the mammalian body where they rapidly respond to host, microbial or environmental stimuli to promote immunity or tissue homeostasis. Furthermore, ILCs are dysregulated in multiple human diseases. Over the past decade, substantial advances have been made in identifying the heterogeneity and functional diversity of ILCs, which have revealed striking similarities to T cell subsets. However, emerging evidence indicates that ILCs also have a complex role in directly influencing the adaptive immune response in the context of development, homeostasis, infection or inflammation. In turn, adaptive immunity reciprocally regulates ILCs, which indicates that these interactions are a crucial determinant of immune responses within tissues. Here, we summarize our current understanding of functional interactions between ILCs and the adaptive immune system, discuss limitations and future areas of investigation, and consider the potential for these interactions to be therapeutically harnessed to benefit human health.
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