期刊
BIOMATERIALS SCIENCE
卷 7, 期 10, 页码 4230-4236出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm00991d
关键词
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资金
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06S029, 2013S086]
- Science and Technology Planning Project of Guangdong Province [2016A010103015]
- Science and Technology Program of Guangzhou [201707010094]
- Science and Technology Planning Project of Shenzhen [JCYJ20170307141438157]
Oxidative damage generated by various biochemical pathways can disrupt the oxidant/antioxidant balance in cells, causing slow wound healing and tissue regeneration; in this regard, a hydrogel dressing with antioxidant properties can promote wound healing; however, its design is still a challenge. Herein, a polydopamine/puerarin (PDA/PUE) nanoparticle-incorporated polyethylene glycol diacrylate hybrid hydrogel (PEG-DA/PDA/PUE) with antioxidant properties was prepared and used as a wound-healing material. Experimental observations indicated that the PEG-DA/PDA/PUE hydrogel possessed excellent swelling capacity and mechanical property. Moreover, the antioxidant capability was enhanced with an increase in the concentration of polydopamine/puerarin nanoparticles in the hydrogel. The hydrogel presented good cell proliferation and antioxidant activity, including a decrease in ROS and increase in the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity under oxidative stress conditions. Furthermore, the full-thickness skin-defect-regeneration process could be accelerated via the antioxidant hydrogel treatment. This study validated the potential applications of an antioxidant hydrogel for wound healing.
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