Cyclodextrine-nanoencapsulation of niclosamide: Water solubility and meaningful enhancement of visible-light Mediated sensitized photodegradation of the drug

A kinetic and mechanistic study of the daylight-mediated photooxidation of the multifunctional drug Niclosamide (NSD) was carried out in aqueous solutions. NSD is a frequent contaminant suspended in natural waters. The aqueous dissolution of the practically insoluble NSD was driven by the presence of 2-hydrxypropyl-P-cyclodextrin (HP beta CD). The already proposed formation of an inclusion complex between NSD-HP beta CD was confirmed through theoretical studies. NSD-nanoencapsulation within the oligosaccharide occurs with a 1:2 stoichiometry, being the drug embedded into a cavity of two HPf3CD molecules, in a so called head-to-head orientation. The Reactive Oxygen Species singlet molecular oxygen, superoxide radical anion and hydrogen peroxide, generated through the visible-light absorber sensitizers Riboflavin and Rose Bengal, are effectively intercepted by the encapsulated biocide and contribute to its photodegradation. The overall NSD photooxidation rate, determined through oxygen consumption indicates that the process is relatively highly efficient in the microheterogeneous aqueous media as compared to NSD in Me0H solution, and to phenol (PHE) in pure water. The paradigmatic water-contaminant PHE was taken a as reference in order to evaluate the persistence of the NSD under photosensitized irradiation in aqueous medium. The photooxidation mechanism of NSD is affected by cyclodextrin complexation, due to dynamic limitations, electrostatic interactions and pH changes upon NSD dissolution in aqueous HIVCD. In this sense, the NSD-HP beta CD complex can be seen as a sort of nanoreactor that enables the photodegradation of the biocide in water, under daylight conditions. (C) 2017 Elsevier B.V. All rights reserved.