期刊
BIOMEDICINES
卷 7, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines7030058
关键词
muscarinic acetylcholine receptor; tuft cell; gastric cancer; colon cancer
资金
- KAKENHI [17K09347, 17H05081]
- P-CREATE from AMED
- Pharmacological Research Foundation
- Bristol-Myers Squibb
- Kowa Life Science Foundation
- Senshin Medical Research Foundation
- Yokoyama Clinical Pharmacological Research Foundation
- Kanae Foundation of the Promotion of Medical Science
- Inoue Science Research Award
- Takeda Science Foundation Visionary Research Grant
- Princess Takamatsu Cancer Research Fund
- Advanced Research and Development Programs for Medical Innovation (PRIME)
- Institute for Adult Diseases, Asahi Life Foundation
- Grants-in-Aid for Scientific Research [17K09347, 17H05081] Funding Source: KAKEN
In the tumor microenvironment, various stromal and immune cells accumulate and interact with cancer cells to contribute to tumor progression. Among stromal players, nerves have recently been recognized as key regulators of tumor growth. More neurotransmitters, such as catecholamines and acetylcholine (ACh), are present in tumors, as the cells that secrete neurotransmitters accumulate by the release of neurotrophic factors from cancer cells. In this short review, we focus on the role of nerve signaling in gastrointestinal (GI) cancers. Given that muscarinic acetylcholine receptor signaling seems to be a dominant regulator of GI stem cells and cancers, we review the function and mechanism of the muscarinic ACh pathway as a regulator of GI cancer progression. Accumulating evidence suggests that ACh, which is secreted from nerves and tuft cells, stimulates GI epithelial stem cells and contributes to cancer progression via muscarinic receptors.
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