期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 133, 期 1, 页码 53-56出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2016.11.005
关键词
Cytokine; Chemokine; Neuroinflammation
资金
- Smoking Research Foundation
- Ministry of Education, Culture, Sports, Science and Technology of Japan [15K10563]
- Grants-in-Aid for Scientific Research [15K10563] Funding Source: KAKEN
Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor alpha 1 was upregulated in accumulating macrophages in the injured SCN after PSL. Treatment with IL-13 reduced inflammatory macrophage-dominant molecules and increased suppressive macrophage-dominant molecules in cultured lipopolysaccharide-stimulated peritoneal macrophages and ex vivo SCN subjected to PSL. Moreover, the perineural administration of IL-13 relieved tactile allodynia after PSL. These results suggest that IL-13 reverses inflammatory macrophage-dependent neuropathic pain via a phenotype shift toward suppressive macrophages. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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