期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 106, 期 9, 页码 2295-2301出版社
WILEY
DOI: 10.1016/j.xphs.2017.03.023
关键词
Drug interactions; Hepatic transport; Transporters; ABC transporters; Bile acid transporters
资金
- Swiss National Science Foundation National Center of Competence in Research TransCure (University of Berne, Switzerland)
Bile formation is a key function of the liver. Disturbance of bile flow may lead to liver disease and is called cholestasis. Cholestasis may be inherited, for example, in progressive familial intrahepatic cholestasis or acquired, for example, by drug-mediated inhibition of bile salt export from hepatocytes into the canaliculi. The key transport system for exporting bile salts into the canaliculi is the bile salt export pump. Inhibition of the bile salt export pump by drugs is a well-established cause of drug-induced cholestasis. Investigation of the role of the multidrug resistance protein 3, essential for biliary phospholipid secretion, is emerging now. This overview summarizes current concepts and methods with an emphasis on in vitro model systems for the investigation of drug-induced cholestasis in the general context of drug-induced liver injury. (C) 2017 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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