期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 134, 期 -, 页码 372-384出版社
ELSEVIER
DOI: 10.1016/j.jpba.2016.10.019
关键词
Abacavir sulfate; Stress testing; Degradation products; Mass spectrometry; NMR spectrometry
In the present study, degradation behaviour of abacavir sulfate was evaluated in solution and solid stress conditions. Solution state studies resulted in formation of eleven degradation products; of which two were also formed on solid stress. The same were separated by high performance liquid chromatography. They were characterized using liquid chromatography-high resolution mass spectrometry, liquid chromatography-multistage mass spectrometry and hydrogen/deuterium exchange mass spectrometry data. Additionally, seven degradation products were isolated and subjected to 1D and 2D nuclear magnetic resonance studies for their structural confirmation. (C) 2016 Elsevier B.V. All rights reserved.
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