期刊
JOURNAL OF PEPTIDE SCIENCE
卷 23, 期 2, 页码 82-94出版社
WILEY
DOI: 10.1002/psc.2954
关键词
peptide hormones; lipopeptides; self-assembly; bioactivity; peptide; therapeutics
资金
- Engineering and Physical Sciences Research Council [1787021] Funding Source: researchfish
- EPSRC [EP/L020599/1] Funding Source: UKRI
This review describes the properties and activities of lipopeptides and peptide hormones and how the lipidation of peptide hormones could potentially produce therapeutic agents combating some of the most prevalent diseases and conditions. The self-assembly of these types of molecules is outlined, and how this can impact on bioactivity. Peptide hormones specific to the uptake of food and produced in the gastrointestinal tract are discussed in detail. The advantages of lipidated peptide hormones over natural peptide hormones are summarised, in terms of stability and renal clearance, with potential application as therapeutic agents. (C) 2017 The Authors Journal of Peptide Science published by European Peptide Society and John Wiley & Sons Ltd.
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