期刊
JOURNAL OF PEDIATRICS
卷 182, 期 -, 页码 217-222出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2016.12.031
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-
类别
资金
- National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health [U01 DK072146, T32 DK067009]
Objectives To assess the accuracy of blood lactate and lactate: pyruvate molar ratio (L: P) as a screen for mitochondrial, respiratory chain, or fatty acid oxidation disorders in children with pediatric acute liver failure (PALF); to determine whether serum lactate >= 2.5 mmol/L or L: P >= 25 correlated with biochemical variables of clinical severity; and to determine whether lactate or L: P is associated with clinical outcome at 21 days. Study design Retrospective review of demographic, clinical, laboratory, and outcome data for PALF study group participants who had lactate and pyruvate levels collected on the same day. Results Of 986 participants, 110 had lactate and pyruvate levels collected on the same day. Of the 110, the etiology of PALF was a mitochondrial disorder in 8 (7%), indeterminate in 65 (59%), and an alternative diagnosis in 37 (34%). Lactate, pyruvate, and L: P were similar among the 3 etiologic groups. There was no significant association between the initial lactate or L: P and biochemical variables of clinical severity or clinical outcome at 21 days. Conclusions A serum lactate >= 2.5 mmol/L and/or elevated L: P was common in all causes of PALF, not limited to those with a mitochondrial etiology, and did not predict 21-day clinical outcome.
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