期刊
MICROBIAL CELL
卷 6, 期 10, 页码 454-481出版社
SHARED SCIENCE PUBLISHERS OG
DOI: 10.15698/mic2019.10.693
关键词
microbiome; indole; tryptophan; bile acids; lactate; vitamins; mental health
资金
- MRC [MR/N014103/1]
- Ontario Brain Institute - Ontario Government
- BBSRC [BB/N005953/1] Funding Source: UKRI
- MRC [MR/N006321/1, 1770810] Funding Source: UKRI
Gastrointestinal and central function are intrinsically connected by the gut microbiota, an ecosystem that has coevolved with the host to expand its biotransformational capabilities and interact with host physiological processes by means of its metabolic products. Abnormalities in this microbiota-gut-brain axis have emerged as a key component in the pathophysiology of depression, leading to more research attempting to understand the neuroactive potential of the products of gut microbial metabolism. This review explores the potential for the gut microbiota to contribute to depression and focuses on the role that microbiallyderived molecules-neurotransmitters, short-chain fatty acids, indoles, bile acids, choline metabolites, lactate and vitamins play in the context of emotional behavior. The future of gut-brain axis research lies is moving away from association, towards the mechanisms underlying the relationship between the gut bacteria and depressive behavior. We propose that direct and indirect mechanisms exist through which gut microbial metabolites affect depressive behavior: these include (i) direct stimulation of central receptors, (ii) peripheral stimulation of neural, endocrine, and immune mediators, and (iii) epigenetic regulation of histone acetylation and DNA methylation. Elucidating these mechanisms is essential to expand our understanding of the etiology of depression, and to develop new strategies to harness the beneficial psychotropic effects of these molecules. Overall, the review highlights the potential for dietary interventions to represent such novel therapeutic strategies for major depressive disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据