期刊
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
卷 4, 期 3, 页码 432-441出版社
VIETNAM NATL UNIV
DOI: 10.1016/j.jsamd.2019.08.001
关键词
Bentonite; Controlled release; Nanocomposite; Kinetics; Alginate
资金
- UGC, New Delhi [2324-MRP/15-16/KLKE015/UGC-SWRO]
The scope of the present study is the synthesis and characterization of a nanocomposite based on natural bentonite clay and sodium alginate as a drug delivery system. The nanocomposite was prepared by the grafted copolymerization of alginate, acrylamide and modified bentonite. The characterization of the nanocomposite was carried out using FTIR, XRD, SEM, TG/DTA, Zeta potential, DLS and TEM analysis. A hydrophilic anticancer drug 5-Flurouracil was chosen as the model drug to investigate the loading and release of the nanocomposite. Swelling profile study revealed that maximum swelling was occurred at pH 6.8. The fitting of Peppas's kinetic model was analysed at pH 6.8 and the release kinetics was found to be more fitted to Korsemeyer-Peppas kinetic model having R-2 = 0.9840. Human Colorectal Adenocarcinoma cells-HT 29 was used for analysing cell viability. The percentage of cell viability decreases from 46.65% to 20.12% when the concentration increases from 2.5 mu g/ml to 10 mu g/ml. As an alternative to in-vivo models the chick embryo chorioallantoic membrane (CAM) study was conducted. The study showed the better biocompatibility and non-toxicity of the nanocomposite. (C) 2019 The Authors. Publishing services by Elsevier B.V. on behalf of Vietnam National University, Hanoi.
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