期刊
JOURNAL OF PATHOLOGY
卷 243, 期 2, 页码 148-154出版社
WILEY
DOI: 10.1002/path.4941
关键词
undifferentiated carcinoma with osteoclast-like giant cells; whole exome sequencing; PDAC variants
资金
- NIH/NCI [P50 CA62924]
- NIH/NIDDK [K08 DK107781]
- Sol Goldman Pancreatic Cancer Research Center
- Buffone Family Gastrointestinal Cancer Research Fund
- Kaya Tuncer Career Development Award in Gastrointestinal Cancer Prevention
- AGA-Bernard Lee Schwartz Foundation
- Sidney Kimmel Foundation
- AACR-Incyte Corporation Career Development Award for Pancreatic Cancer Research
- Rolfe Pancreatic Cancer Foundation
- Joseph C Monastra Foundation
- The Gerald O Mann Charitable Foundation
- Sigma Beta Sorority
- Associazione Italiana per la Ricerca sul Cancro [12182]
- Cam-Pac [602783]
- Ministero della Salute [FIMP-CUP_J33G13000210001]
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGC) is currently considered a morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC). In this study, we report clinical and pathological features of a series of 22 UCOGCs, including the whole exome sequencing of eight UCOGCs. We observed that 60% of the UCOGCs contained a well-defined epithelial component and that patients with pure UCOGC had a significantly better prognosis than did those with an UCOGC with an associated epithelial neoplasm. The genetic alterations in UCOGC are strikingly similar to those known to drive conventional PDAC, including activating mutations in the oncogene KRAS and inactivating mutations in the tumor suppressor genes CDKN2A, TP53, and SMAD4. These results further support the classification of UCOGC as a PDAC variant and suggest that somatic mutations are not the determinants of the unique phenotype of UCOGC. Copyright (C) 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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