3.8 Article

BRCA1-BARD1: the importance of being in shape

期刊

MOLECULAR & CELLULAR ONCOLOGY
卷 6, 期 6, 页码 -

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2019.1656500

关键词

BRCA1; BARD1; PIN1; fork protection; isomerization; RAD51

类别

资金

  1. CRUK Center training
  2. HEFCE
  3. Breast Cancer Now
  4. Wellcome Trust
  5. Higher Education Funding Council for England
  6. University of Birmingham
  7. Cancer Research UK
  8. [CRUK: C8820/A19062]

向作者/读者索取更多资源

The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.

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