期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 6, 期 6, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2019.1656500
关键词
BRCA1; BARD1; PIN1; fork protection; isomerization; RAD51
类别
资金
- CRUK Center training
- HEFCE
- Breast Cancer Now
- Wellcome Trust
- Higher Education Funding Council for England
- University of Birmingham
- Cancer Research UK
- [CRUK: C8820/A19062]
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.
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