期刊
ENDOCRINE
卷 66, 期 1, 页码 35-42出版社
SPRINGER
DOI: 10.1007/s12020-019-02044-2
关键词
Pregnancy; Hypothyroidism; TSH; FT4; Levothyroxine
资金
- Chinese National Natural Science Foundation [81570709, 81170730]
- National Science and Technology Support Program [2014BAI06B02]
- Research Foundation of Key Laboratory of Endocrine Diseases, Department of Education in Liaoning Province China [LZ2014035]
- Key Platform Foundation of Science and Technology for the Universities in Liaoning Province [16010]
- Health and Medicine Research Foundation, Shenyang City [17-230-9-02]
Hypothyroidism is the most frequent pregnancy-related thyroid dysfunction, including overt and subclinical hypothyroidism. Studies show that even mild hypothyroidism may eventuate in adverse gestational outcomes and intellectual impairment of offspring. Women with overt hypothyroidism (OH) must be treated by levothyroxine (LT4) pre- and during pregnancy, however, it is controversial that when and how to initiate LT4 therapy and further optimize dosing so that pregnant women and their offspring may truly benefit. In the review we will analyze the changes in thyroid hormone requirements in pregnant women, the timing of LT4 treatment and adjustment of LT4 dose according to etiology in patients with hypothyroidism during pregnancy, and adjustment of LT4 after delivery.
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