期刊
DIGESTIVE AND LIVER DISEASE
卷 47, 期 12, 页码 997-1006出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2015.08.004
关键词
Dyslipidaemia; Metabolic syndrome; NAFLD; Obesity; Type 2 diabetes mellitus
An improved understanding of non-alcoholic fatty liver disease epidemiology would lead to identification of individuals at high risk of developing chronic liver disease and extra-hepatic complications, thus contributing to more effective case finding of non-alcoholic fatty liver disease among selected groups. We aimed to illustrate the epidemiology of non-alcoholic fatty liver disease in high-risk groups, which were identified based on existing literature. To this end, PubMed was searched to retrieve original articles published until May 2015 using relevant and pertinent keywords nonalcoholic fatty liver disease and diabetes, obesity, hyperlipidaemia, familial heterozygous hypobetalipoproteinaemia, hypertension, metabolic syndrome, ethnicity, family history or genetic polymorphisms. We found that age, sex and ethnicity are major physiological modifiers of the risk of non-alcoholic fatty liver disease, along with belonging to non-alcoholic fatty liver disease families and carrying risk alleles for selected genetic polymorphisms. Metabolic syndrome, diabetes, obesity, mixed hyperlipidaemia and hypocholesterolaemia due to familial hypobetalipoproteinaemia are the major metabolic modifiers of non-alcoholic fatty liver disease risk. Compared with these metabolic conditions, however, arterial hypertension appears to carry a relatively more modest risk of non-alcoholic fatty liver disease. A better understanding of the epidemiology of non-alcoholic fatty liver disease may result in a more liberal policy of case finding among high-risk groups. (C) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据