期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 35, 期 8, 页码 1573-1588出版社
WILEY
DOI: 10.1002/jor.23563
关键词
osteoarthritis; systems biology; cartilage; modelling
类别
资金
- Wellcome Trust [107471/Z/15/Z]
- Biotechnology and Biological Sciences Research Council [BB/H531951/1]
- Wellcome Trust [107471/Z/15/Z] Funding Source: Wellcome Trust
- MRC [MR/K006312/1] Funding Source: UKRI
- Medical Research Council [MR/K006312/1] Funding Source: researchfish
- Wellcome Trust [107471/Z/15/Z] Funding Source: researchfish
Systems orientated research offers the possibility of identifying novel therapeutic targets and relevant diagnostic markers for complex diseases such as osteoarthritis. This review demonstrates that the osteoarthritis research community has been slow to incorporate systems orientated approaches into research studies, although a number of key studies reveal novel insights into the regulatory mechanisms that contribute both to joint tissue homeostasis and its dysfunction. The review introduces both top-down and bottom-up approaches employed in the study of osteoarthritis. A holistic and multiscale approach, where clinical measurements may predict dysregulation and progression of joint degeneration, should be a key objective in future research. The review concludes with suggestions for further research and emerging trends not least of which is the coupled development of diagnostic tests and therapeutics as part of a concerted effort by the osteoarthritis research community to meet clinical needs. (C) 2017 The Authors.
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