期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 36, 期 2, 页码 620-631出版社
WILEY
DOI: 10.1002/jor.23757
关键词
articular cartilage; chondrocyte; biomechanics; functional study; imaging
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [069047, 063642]
- National Science Foundation [CBET1253189]
- National Institute of General Medical Sciences [GM104937]
- Canadian Institutes of Health Research [FDN-143341]
Mature chondrocytes in adult articular cartilage vary in number, size, and shape, depending on their depth in the tissue, location in the joint, and source species. Chondrocytes are the primary structural, functional, and metabolic unit in articular cartilage, the loss of which will induce fatigue to the extracellular matrix (ECM), eventually leading to failure of the cartilage and impairment of the joint as a whole. This brief review focuses on the functional and biomechanical studies of chondrocytes and articular cartilage, using microscopic imaging from optical microscopies to scanning probe microscopy. Three topics are covered in this review, including the functional studies of chondrons by optical imaging (unpolarized and polarized light and infrared light, two-photon excitation microscopy), the probing of chondrocytes and cartilage directly using microscale measurement techniques, and different imaging approaches that can measure chondrocyte mechanics and chondrocyte biological signaling under in situ and in vivo environments. Technical advancement in chondrocyte research during recent years has enabled new ways to study the biomechanical and functional properties of these cells and cartilage. (c) 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:620-631, 2018.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据