期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 2, 页码 1114-1126出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02731
关键词
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资金
- DST-India [SB/S1/OC-10/2014]
- CSIR-India [02(205)/14/EMR-II]
- UGC-India
- IISERB
A palladium-catalyzed, ortho-selective C-H halogenation methodology is reported herein. The highlight of the work is the highly selective C(sp(2))-H functionalization of benzyl nitriles in the presence of activated C(sp(3))-H bond, which results in good yields of the halogenated products with excellent regioselectivity. Along with benzyl nitriles, aryl Weinreb amides and anilides have been evaluated for the transformation using aprotic conditions. Mechanistic studies yield interesting aspects with respect to the pathway of the reaction and the directing group abilities.
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