期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 14, 页码 7165-7175出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00643
关键词
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资金
- Council of Scientific & Industrial Research (CSIR), New Delhi [01(5234)/15]
- Department of Science & Technology (DST) [YSS/2015/001552]
- CSIR
- DST
- IIESTS
In this paper, we report a general, efficient, and environmentally benign method for the one-pot cascade synthesis of quinazolin-4(3H)-ones via acceptorless dehydrogenative coupling of o-aminobenzamide with alcohols catalyzed by a simple Ni(II) catalyst, [Ni(MeTAA)], featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeTAA)). A wide variety of substituted quinazolin-4(3H)-ones were synthesized in high yields starting from readily available benzyl alcohols and o-aminobenzamides. Several controlled reactions along with deuterium labeling studies were carried out to establish the acceptorless dehydrogenative nature of the reactions.
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