期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 23, 页码 12603-12612出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02363
关键词
-
资金
- Chinese Academy of Sciences (Strategic Priority Research Program) [XDB20020200, QYZDJ-SSW-SLH029]
- National Natural Science Foundation of China [21621002]
N,N'-Bis(furan-2-ylmethyl)oxalamide (BFMO), an inexpensive and conveniently available bidentate ligand, is very effective for promoting Cu-catalyzed N-arylation of anilines and cyclic secondary amines. The method enables coupling of a broad range of (hetero)aryl bromides with various (hetero)aryl amines and cyclic secondary amines at 0.5-5 mol % catalyst loadings at relatively low temperatures. For coupling with more sterically hindered acyclic secondary amines, using N,N'-bis(2,4,6-trimethoxyphenyl)oxalamide (BTMPO) as a ligand gives the better results. Additionally, high selectivity is achieved in CuI/BFMO-catalyzed direct monoarylation of piperazine with (hetero)aryl bromides to afford pharmaceutically important building blocks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据