期刊
THERANOSTICS
卷 9, 期 25, 页码 7849-7871出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.37218
关键词
small molecules; theranostic agents; cancer immunology; molecular imaging; targeted therapy
资金
- USC Research Center for Liver Diseases Pilot Funding (NIH) [P30 DK048522]
- Whittier Foundation for Translational Research
- USC Department of Radiology
- China Scholarship Council (CSC) program [201806310056]
With further research into the molecular mechanisms and roles linking immune suppression and restraint of (pre)malignancies, immunotherapies have revolutionized clinical strategies in the treatment of cancer. However, nearly 70% of patients who received immune checkpoint therapeutics showed no response. Complementary and/or synergistic effects may occur when extracellular checkpoint antibody blockades combine with small molecules targeting intracellular signal pathways up/downstream of immune checkpoints or regulating the innate and adaptive immune response. After radiolabeling with radionuclides, small molecules can also be used for estimating treatment efficacy of immune checkpoint blockades. This review not only highlights some significant intracellular pathways and immune-related targets such as the kynurenine pathway, purinergic signaling, the kinase signaling axis, chemokines, etc., but also summarizes some attractive and potentially immunosuppression-related small molecule agents, which may be synergistic with extracellular immune checkpoint blockade. In addition, opportunities for small molecule-based theranostics in cancer immunology will be discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据