期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 15, 页码 8304-8308出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01381
关键词
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资金
- JST, ACT-C [JPMJCR12YO]
- KAKENHI from JSPS [25713002, 16K18856]
- JSPS KAKENHI [JP16H01043]
- Naito Foundation
- Kumagai Foundation for Science and Technology
- JSPS
- Grants-in-Aid for Scientific Research [17H03025, 16K18856, 16H01043] Funding Source: KAKEN
Direct asymmetric aldol addition of an alpha-CF3 amide to arylglyoxal hydrates was promoted by a chiral catalyst comprising a soft Lewis acidic Cu(I), a chiral bisphosphine ligand, and DBU. The 7-azaindoline moiety of the amide facilitates its enolization and stabilizes the thus-generated Cu enolate, furnishing enantioenriched aldol adducts.
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