期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 10, 页码 5263-5273出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00575
关键词
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资金
- National Natural Science Foundation of China [81620108027, 21632008, 91229204, 81220108025]
- Chinese National Programs for Fundamental Research and Development [2015CB910304]
- National S&T Major Projects [2014ZX09507002-001]
Ru(II)-catalyzed redox-neutral [3+2] annulation reactions of N-ethoxycarbamoyl indoles and internal alkynes via C-H bond activation are reported. This method features a broad internal alkyne scope, including various aryl/alkyl-, alkyl/alkyl-, and diaryl-substituted alkynes, good to excellent regioselectivity, diverse functional group tolerance, and mild reaction conditions. The N-ethoxycarbamoyl directing group, temperature, CsOAc, and ruthenium catalyst proved to be crucial for conversion and high regioselectivity. Additionally, preliminary mechanistic experiments were conducted, and a possible mechanism was proposed.
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