期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 1, 页码 145-153出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02483
关键词
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资金
- National Natural Science Foundation of China [21502042, 51403051, 21204018]
- Scientific Research Key Project Fund of Henan Provincial Education Department [15A150041, 16A150003]
- Scientific Research Fund of Henan University [2013YBZR008]
A simple and direct method for the iron(III) nitrate-mediated synthesis of isoxazoles from alkynes has been developed; both self-coupling and cross-coupling products could be successfully prepared from alkynes. Meanwhile, for the cross-coupling and cyclizing of two different alkynes examined, the iron-mediated system shows a good chemoselectivity for the synthesis of corresponding isoxazoles. In our method, cheap and eco-friendly iron(III) nitrate is used as the nitration and cyclization reagent, and KI is used as the additive; they both play a positive role in this transformation. Furthermore, a different mechanism for the formation of isoxazoles from alkynes has been proposed.
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