期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 21, 页码 11348-11357出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01635
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资金
- National Natural Science Foundation of China [NNSFC-21372040, 21672032]
- State Key Laboratory of Fine Chemicals [KF1502]
- Foundation of Jilin Educational Committee [JJKH20170907KJ]
DBU-catalyzed sequential intermolecular and intramolecular nucleophilic addition reactions between gem-difluoroolefins and o-hydroxy/mercapto benzaldehydes have been developed to provide a [4 + 2] annulation strategy for facile synthesis of gem-difluorinated isoflavanol derivatives. The competitive addition elimination reaction of gem-difluoroolefins with nucleophiles was avoided under mild conditions, affording 2,2-difluorinated 4-isoflavanols or 2,2-difluoriated 4-thioisoflavanols in good to excellent yields.
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