期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 19, 页码 9931-9936出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00459
关键词
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资金
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM097243]
While the use of triphenylphosphine as a reductant is common in organic synthesis, the resulting triphenylphosphine oxide (TPPO) waste can be difficult to separate from the reaction product. While a number of strategies to precipitate TPPO are available, none have been reported to work in more polar solvents. We report here that mixing ZnCl2 with TPPO precipitates a TPPO-Zn complex in high yield in several common polar organic solvents. The solvent compatibility of this procedure and the reliability of the precipitation in the presence of polar functional groups were examined to show the utility and limitations of this method.
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