期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 19, 页码 9978-9987出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01303
关键词
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资金
- National Natural Science foundation of China [21425415, 21274058]
- National Basic Research Program of China [2015CB856303]
We report herein a Rh(III)-catalyzed alkenyl CH activation protocol for the coupling of oxadiazoles with alkynes and synthesis of 2-acylamino and 2-amino pyridines, an important heterocyclic scaffold for various naturals products and synthetic pharmaceuticals bearing a readily reacting functional group. The selective protection/deprotection of amino groups through simple solvent switching, good functional group compatibility, superior product yield, and high regioselectivity are some of the notable synthetic features witnessed in this reaction protocol.
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