期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 9, 页码 4918-4923出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00259
关键词
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资金
- Major Natural Science Foundation of Jiangsu Province [14KJA150004]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A consecutive Sonogashira coupling reaction, acetylene hydroamination cyclization of 2-(2-bromophenyl)quinazolin-4(3H)-ones and terminal alkynes, is described catalyzed by CuI/L-proline in the presence of Cs2CO3. This procedure provided a facile method for the synthesis of isoindolo[1,2-b]quinazolin-10(12H)-one derivatives in good yields.
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