期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 9, 页码 4774-4783出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00461
关键词
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资金
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02-06]
- Fundamental Research Funds for the Central Universities [201562031]
The asymmetric organocatalyzed diversity-oriented one-pot synthesis has been developed to construct chroman2-one derivatives and other heterocyclic compounds with excellent efficiency and stereoselectivity. The reactions represent a challenging issue, since it altered the inherent selectivity profiles exhibited by the substrates of 2-hydroxycinnamaldehyde 1 and trans-beta-nitrostyrene 2, which was previously reported as the asymmetric oxa-Michael Michael cascade to generate chiral chromans. It should be noted that polycyclic O,O-acetal-containing compounds, which are found in numerous natural products and biologically interesting molecules, could also be achieved in good yields with excellent enantioselectivity as a single diastereoisomer with five continuous stereogenic centers.
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