期刊
CHEMICAL SCIENCE
卷 10, 期 40, 页码 9292-9301出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc03081f
关键词
-
资金
- National Natural Science Foundation of China [NSFC 21702211, 21773051, 21703051, 21801056]
- Natural Science Foundation of Jiangsu Province [BK20170421]
- Zhejiang Provincial Natural Science Foundation of China [LZ18B020001, LY17B030005]
A novel Pd/Cu-cocatalyzed carbonylative cyclization by C-H activation and N-dealkylative C-N bond activation has been developed for the chemoselective construction of synthetically useful heterocycles. The N,N-dimethylamine group on o-indolyl-N,N-dimethylarylamines was found to act as both the directing group and reactive component in this C-H carbonylative cyclization reaction. Furthermore, a unique C-H oxidation/carbonylative lactonization of diarylmethylamines is firstly demonstrated under modified reaction conditions, which could be easily applicable to the one-step synthesis of multi-substituted phthalides bearing an N,O-ketal skeleton that is difficult to access by previously reported methods. Mechanistic studies implicate that Pd/Cu-cocatalyzed C-H oxidation/carbonylative lactonization is a sequential reaction system via Cu-catalyzed C(sp(3))-H oxidation and Pd-catalyzed oxidative carbonylation of the C(sp(2))-H bond. It was found that trace amounts of water are essential to promote the Cu-catalyzed C(sp(3))-H oxidation of diarylmethylamine for the formation of the hydroxyl group, which could act as an in situ-formed directing group in the intramolecular carbonylative lactonization step.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据