期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 18, 页码 9505-9514出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01529
关键词
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资金
- University of Costa Rica
- Sistema de Estudios de Posgrado (SEP-UCR)
Sequential treatment of 2,3-dichloropropene with magnesium and n-BuLi generated the equivalent of 1,3dilithiopropyne, which adds regiospecifically to aldehydes and ketones to produce homopropargyl alcohols. The lithium acetylide intermediate formed in this protocol can be further reacted with aromatic and vinyl halides, under palladium catalysis, to produce 4-substituted homopropargyl alcohols and 5-en-3-yn-1-ols, respectively, in one-pot with good overall yields.
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