期刊
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
卷 65, 期 3, 页码 245-251出版社
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
DOI: 10.3164/jcbn.19-48
关键词
vitamin D; interstitial pneumonia; pulmonary fibrosis; prevention
资金
- MEXT-Supported Program for the Strategic Research Foundation at Private Universities [S1511018]
Calcitriol [1,25(OH)(2)D-3] is usually investigated in studies on the preventive effect of activated vitamin D against interstitial pneumonia. Although cholecalciferol (vitamin D-3) can be easily obtained in the diet and has a longer half-life than calcitriol, there have been few investigations of its effect on interstitial pneumonia. We used human pulmonary fibroblast cell lines (HPFCs) and a mouse model of bleomycin-induced pulmonary fibrosis to evaluate whether vitamin D-3 was activated in the lungs and had a preventive effect against interstitial pneumonia. Expression of the vitamin D receptor gene and genes for enzymes metabolizing vitamin D was evaluated in two HPFCs, and the suppressive effect of vitamin D-3 on induction of inflammatory cytokines was also assessed. Gene expression of the vitamin D receptor and vitamin D-metabolizing enzymes was observed in both human pulmonary fibroblast cell lines. Vitamin D-3 suppressed bleomycin-induced expression of inflammatory cytokines and fibrosis markers by the HPFCs. In mice, symptoms of bleomycin-induced pulmonary fibrosis were improved and expression of fibrosis markers/fibrosis inducers was decreased by a high vitamin D-3 diet. Vitamin D-3 is activated locally in lung tissues, suggesting that high dietary intake of vitamin D-3 may have a preventive effect against interstitial pneumonia.
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