期刊
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
卷 59, 期 7, 页码 679-690出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0000000000001053
关键词
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资金
- National Institute of Occupational Safety and Health Education Research Center (NIOSH/ERC) Small Project/Pilot Study Grants via the University of Alabama at Birmingham (UAB) [5T42OH008436-10]
- University of Georgia
Objective:A repeated measures study was used to assess the effect of work tasks on select proinflammatory biomarkers in firefighters working at prescribed burns.Methods:Ten firefighters and two volunteers were monitored for particulate matter and carbon monoxide on workdays, January to July 2015. Before and after workshift dried blood spots were analyzed for inflammatory mediators using the Meso Scale Discovery assay, while blood smears were used to assess leukocyte parameters.Results:Firefighters lighting with drip-torches had higher cross-work-shift increases in interleukin-8, C-reactive protein, and serum amyloid A compared with holding, a task involving management of fire boundaries. A positive association between interleukin-8 and segmented-neutrophil was observed.Conclusion:Results from this study suggest that intermittent occupational diesel exposures contribute to cross-work-shift changes in host systemic innate inflammation as indicated by elevated interleukin-8 levels and peripheral blood segmented-neutrophils.
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