期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 48, 期 -, 页码 51-61出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2017.06.011
关键词
Rice bran enzymatic extract; Ferulic acid; Atherosclerosis; Mitochondrial function; Oxidative stress
资金
- Corona Foundation via the Stifterverband fur die Deutsche Wissenschaft [S199/10060/2014]
- Spanish Government by FPU [AP2012-2607]
The aim of the study was to characterize the vascular effects of rice bran enzymatic extract (RBEE). ApoE-/- mice were fed a high-fat/cholesterol diet (HFD) or HFD supplemented with 5% RBEE for 21 weeks. RBEE prevented development of atherosclerotic plaques and oxidative stress in mouse aorta as well as the down-regulation of markers of mitochondrial biogenesis. Analysis of the bioactive components identified ferulic acid (FA) as responsible component. In healthy human volunteers, FA intake reduced NADPH oxidase activity, superoxide release, apoptosis and necrosis in peripheral blood mononuclear cells. Differentiation and proliferation of endothelial progenitor cells were improved. In summary, the study identifies FA as a major active component of rice bran, which improves expression of mitochondrial biogenesis and dynamics markers and reduces oxidative stress in a mouse model of vascular damage as well as in endothelial cells and human mononuclear cells. (C) 2017 Elsevier Inc. All rights reserved.
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