期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 39, 期 -, 页码 134-144出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2016.10.004
关键词
Brain-derived neurotrophic factor; Depression; Inflammation; Nrf2; Prevention; Sulforaphane; Synaptogenesis
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- SENSHIN Medical Research Foundation, Japan
- Ishidsu Shun Memorial Scholarship (Tokyo, Japan)
- Uehara Memorial Foundation (Tokyo, Japan)
- Japan Society for the Promotion of Science
- Leading Graduate School at Chiba University
- Japan Society for the Promotion of Science (JSPS) (Tokyo, Japan)
- Grants-in-Aid for Scientific Research [15K19711] Funding Source: KAKEN
Inflammation plays a role in the pathophysiology of depression. Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation. In this study, we examined whether the prevention effects of SFN in lipopolysaccharide (LPS) induced depression-like behavior in mice. Pretreatment with SFN significantly blocked an increase in the serum tumor necrosis factor-alpha (TNF-alpha) level and an increase in microglial activation of brain regions after a single administration of LPS (0.5 mg/kg). Furthermore, SFN significantly potentiated increased serum levels of IL-10 after LPS administration. In the tail-suspension test and forced swimming test, SFN significantly attenuated an increase of the immobility time after LPS administration. In addition, SFN significantly recovered to control levels for LPS-induced alterations in the proteins such as brain-derived neurotrophic factor, postsynaptic density protein 95 and AMPA receptor 1 (GluA1) and dendritic spine density in the brain regions. Finally, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food during the juvenile and adolescence could prevent the onset of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions at adulthood. In conclusion, these findings suggest that dietary intake of SFN-rich broccoli sprout has prophylactic effects on inflammation-related depressive symptoms. Therefore, supplementation of SFN-rich broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients. (C) 2016 Elsevier Inc. All rights reserved.
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