期刊
JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS
卷 10, 期 5-6, 页码 139-145出版社
KARGER
DOI: 10.1159/000484480
关键词
Vitamin D; Cross-linked C-telopeptide; Parathyroid hormone; Procollagen 1 N-terminal; Genistein; Polymorphism
Aims: The objective of this study was to determine whether vitamin D and genistein supplementation had an additive beneficial effect on levels of vitamin D and bone markers and whether this effect was mediated by genes regulating isoflavone metabolism. Materials and Methods: We carried out a prospective study in postmenopausal women randomized to calcium and vitamin D supplementation or calcium, vitamin D, and genistein supplementation. Vitamin D, parathyroid hormone (PTH), cross-linked C-telopeptide (CTX), and procollagen 1 N-terminal (P1NP) were determined by electrochemiluminescence. Three SNPs - rs2231142 (ABCG2), rs358231 (cytosolic beta-glucosidase [CBG]), and rs2273697 (ABCC2) - were determined. Results: We included 102 women. The effects on bone remodeling were similar: rises in vitamin D were significantly associated with reductions in PTH, CTX, and P1NP. Pharmacogenomic analysis of the genotypes showed that, in AT heterozygotes of the CBG1368T>A polymorphism, CTX and P1NP were not reduced. Conclusion: Genistein added to calcium and vitamin D supplementation had no additional effect. The supplementation of individual AT heterozygotes of the CBG1368T>A polymorphism had no effect on markers of bone remodeling. (C) 2017 S. Karger AG, Basel
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