期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 86, 页码 12916-12919出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc07380a
关键词
-
资金
- NSFC [21672052]
- PhD research foundation of Henan University of Technology [2019BS003]
An enantioselective aerobic decarboxylative Povarov reaction of N-aryl alpha-amino acids with methylenephthalimidines through cooperative photoredox and chiral Bronsted acid catalysis is reported. With a transition metal-free dual catalytic system including a chiral phosphoric acid and DPZ as a photosensitizer mediated by visible light, the transformations provided a series of valuable chiral isoindolin-1-ones containing a 3,3-spiro-tetrahydroquinoline-based stereocenter in high yields (up to 83%) with good to excellent enantioselectivities (up to 98% ee) and excellent diastereoselectivity (>20 : 1 dr).
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