期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 82, 页码 12352-12355出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc06674h
关键词
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资金
- National Key Basic Research Program of China [2015CB5540007]
- National Natural Science Foundation of China Programs [81572866, 81671904, 81773104, 21708008, 81472740, 81873931, 81773263]
- Natural Science Foundation Program of Hubei Province [2018CFB474]
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College of HUST
- Academic Medical Doctor Supporting Program, Tongji Medical College, HUST
- Major Scientific and Technological Innovation Projects in Hubei Province [2018ACA136]
We report a new biofunctionalized nanoplatform based on hyaluronic acid-coated gold-nano-dot-decorated hollow carbon nanospheres (AuHCNs-HA) for microRNA imaging in living cells. Importantly, the HA-coated nanoplatform could be internalized into target cells via CD44 receptor-mediated endocytosis. It can be further applied for intracellular miR-21 imaging in CD44-positive colorectal cancer cells.
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