期刊
JOURNAL OF NUCLEAR CARDIOLOGY
卷 25, 期 6, 页码 2016-2023出版社
SPRINGER
DOI: 10.1007/s12350-017-0914-z
关键词
Myocardial perfusion imaging; CZT camera; dual-isotope protocol; Sestamibi; thallium-201
资金
- French health ministry (inter-regional GIRCI)
Purpose of the reportThis study aimed at assessing an original low-dose dual-isotope procedure in which the abnormal stress Tc-99m Sestamibi SPECT is followed by rest Tl-201 SPECT, along with a head-to-head comparison with a single-isotope procedure.Methods and resultsOne hundred two patients, referred for a low-dose stress-SPECT with Sestamibi (12320MBq) on a CZT camera and for whom a rest Sestamibi SPECT was warranted, had an additional Tl-201 rest-SPECT (52 +/- 5MBq) between stress and rest Sestamibi SPECT recordings. Tl-201 images were processed for spill-over and scatter corrections, and uptake differences with stress Sestamibi SPECT were analyzed: (1) for rest acquisitions from Tl-201 (dual-isotope procedure) and from Sestamibi (single-isotope procedure) and (2) in segments for which a diagnosis of ischemia, infarct, or normal perfusion was achieved. Mean effective dose was 8.3mSv for dual-isotope but would decrease to 5.7mSv for an expected rate of 37% of patients for whom rest-SPECT is not warranted. After a further background correction of Tl-201 images, the rest-stress difference in myocardial uptake was equivalent between dual- and single-procedures for identifying ischemic segments (respective areas-under-curves: 0.83 +/- 0.03 and 0.81 +/- 0.03).Conclusion This original dual-isotope procedure provides acceptable radiation doses and consistent results, as compared with conventional single-isotope.
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