期刊
JOURNAL OF NEUROTRAUMA
卷 34, 期 -, 页码 S6-S17出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2017.5220
关键词
blast injury; chronic traumatic encephalopathy; neurodegeneration; repetitive head trauma; traumatic brain injury
资金
- NIA NIH HHS [R01 AG046319] Funding Source: Medline
- NINDS NIH HHS [U01 NS096835] Funding Source: Medline
- BLRD VA [I01 BX002311] Funding Source: Medline
- RRD VA [I01 RX000996] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U01NS096835] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG046319] Funding Source: NIH RePORTER
- Veterans Affairs [I01RX000996, I01BX002311] Funding Source: NIH RePORTER
- VA [5I01BX002311-04] Funding Source: Federal RePORTER
Blast-related traumatic brain injury (TBI) is a signature injury of recent military conflicts, leading to increased Department of Defense (DoD) interest in its potential long-term effects, such as chronic traumatic encephalopathy (CTE). The DoD Blast Injury Research Program Coordinating Office convened the 2015 International State-of-the-Science Meeting to discuss the existing evidence regarding a causal relationship between TBI and CTE. Over the course of the meeting, experts across government, academia, and the sports community presented cutting edge research on the unique pathological characteristics of blast-related TBI, blast-related neurodegenerative mechanisms, risk factors for CTE, potential biomarkers for CTE, and treatment strategies for chronic neurodegeneration. The current paper summarizes these presentations. Although many advances have been made to address these topics, more research is needed to establish the existence of links between the long-term effects of single or multiple blast-related TBI and CTE.
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