期刊
DIAGNOSTIC PATHOLOGY
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13000-015-0445-3
关键词
MMP-9; TN-C; ECM; Prognosis; Pancreatic cancer
类别
资金
- project of National Natural Science Fund [81272363, 81430063]
- National 863 Project of China [2012AA02A201]
- Chongqing Natural Science Fund Project [2012JB1032]
Background: Matrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression of these two molecules and the clinical prognosis of pancreatic cancer. Methods: We investigated the expression of TN-C and MMP-9 in 103 pancreatic cancer tissues by immunohistochemistry and used statistical analyses to investigate the correlations of individual expression or co-expression of these two molecules with clinicopathological parameters and survival of pancreatic cancer. Results: The expression of MMP-9 and TN-C were increased in pancreatic cancer. The co-expression of MMP-9 and TN-C was also detected. The expression of MMP-9 and TN-C were correlated with vascular invasion, lymph node invasion, liver metastases and TNM stage. The co-expression of MMP-9 and TN-C was significantly related to the pancreatic cancer metastases. The individual overexpression of MMP-9 or TN-C significantly decreased the overall survival rates. The co-expression of MMP-9 and TN-C had the lowest overall survival rates. The co-expression of MMP-9 and TN-C was an independent predictor of survival for pancreatic cancer patients. Conclusions: Co-expression of MMP-9 and TN-C was associated with poorer prognosis and was found to be an independent predictor of survival.
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