期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 95, 期 11, 页码 2267-2274出版社
WILEY
DOI: 10.1002/jnr.23998
关键词
glucose transporter; Slc2a1; endothelium; astrocyte; Alzheimer disease; GLUT1 deficiency
资金
- Fondecyt [1160317, 11150930, 3160131]
- Chilean Government through Centers of Excellence Basal Financing Program of CONICYT
Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity. We discuss how the architecture of the blood-brain barrier and the low concentration of glucose within neurons combine to make endothelial/glial GLUT1 the master controller of neuronal glucose utilization, while the regulatory role of the neuronal glucose transporter GLUT3 emerges as secondary. The nearcritical condition of glucose dynamics in the brain suggests that subtle deficits in GLUT1 function or its activity-dependent control by neurons may contribute to neurodegeneration. (C) 2017 Wiley Periodicals, Inc.
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