期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 96, 期 3, 页码 354-359出版社
WILEY
DOI: 10.1002/jnr.24154
关键词
spontaneous; miniature; neurotransmitter release; synapse formation; development; dendritic arbor
资金
- BBSRC
- NARSAD Young Investigator Award
- Wellcome Trust Investigator Award
- ERC
- EU
- BBSRC [BB/P000479/1] Funding Source: UKRI
- MRC [MR/N026063/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/P000479/1] Funding Source: researchfish
- Medical Research Council [MR/N026063/1] Funding Source: researchfish
In the past, the spontaneous release of neurotransmitter from presynaptic terminals has been thought of as a side effect of evoked release, with little functional significance. As our understanding of the process of spontaneous release has increased over time, this notion has gradually changed. In this review, we focus on the importance of this form of release during neuronal development, a time of extreme levels of plasticity that includes the growth of dendrites and axons as well as the formation of new synaptic contacts. This period also encompasses high levels of neurotransmitter release from growing axons, and recent studies have found that spontaneous transmitter release plays an important role in shaping neuronal morphology as well as modulating the properties of newly forming synaptic contacts in the brain. Here, we bring together the latest findings across different species to argue that the spontaneous release of neurotransmitter is an important player in the wiring of the brain during development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据