期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 96, 期 5, 页码 781-788出版社
WILEY
DOI: 10.1002/jnr.24200
关键词
autism; neurite outgrowth; oxytocin; Rho GTPase; SHANK proteins
资金
- Grant Agency of Ministry of Education and Slovak Academy of Sciences (VEGA) [2/0119/15, 2/0116/16]
- Slovak Research and Development Agency [APVV-15-205]
Accumulating evidence suggests that Rho GTPases, together with scaffolding SHANK proteins, and associated signaling pathways play a role in the development of autism symptoms in various conditions. Research data have brought information on multiple intracellular signaling pathways, including Rho-associated protein kinases and serine/threonine-protein kinases involved in cytoskeleton rearranging. Alterations in downstream effectors of GTPase signaling pathways are associated with neurodevelopmental disorders. Bioinformatics and experimental data show that complex genetic and molecular defects (GTPases, actin-binding proteins, kinases, neuropeptides) can result in neuronal remodeling, leading to the functional connectivity deficits that manifest as the heterogeneous autism spectrum phenotype. Finally, the known hormone and neuropeptide oxytocin appears to be a factor for consideration in therapeutic intervention.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据