期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 81, 期 2, 页码 126-131出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2014.10.008
关键词
ETEC; PFGE; MIST; Virulence gene; Antimicrobial susceptibility
资金
- National High Technology Research and Development Program of China (863 Program) [2012AA101601]
- Mega-projects of Science and Technology Research of China [2012ZX10004215-003, 2012ZX10004201]
- Research Projects of Health and Family Planning Commission of Changning District of Shanghai [20134GW24001]
- Research Projects of Health and Family Planning Commission of Putuo District of Shanghai [PU-KW12314]
A total of 123 enterotoxigenic Escherichia coli (ETEC) isolates from diarrheal patients from June to December 2012 in Shanghai, China, were examined to determine their genetic relatedness using multilocus sequence typing and pulsed-field gel electrophoresis (PFGE) and for the presence of virulence genes and antimicrobial susceptibility. Twenty-nine sequence types (STs) and 63 PFGE patterns were identified, and results from the 2 subtyping methods correlated well. The 12 isolates of PFGE cluster B all belonged to ST-2332 and were associated with nosocomial neonatal diarrhea. Isolates of a cluster usually had the same set of virulence factors, whereas isolates of different PFGE clusters carried diverse combinations of virulence determinants. Isolates belonging to ST-2332 and ST-182 (n = 9) were resistant to at least 6 antimicrobials. Our findings highlighted the need of active surveillance programs for infectious diseases collecting data at both epidemiological and genetic levels that can detect high-risk lineages of pathogens in order to rapidly identify disease outbreaks. (C) 2015 Elsevier Inc. All rights reserved.
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