期刊
JOURNAL OF NEUROSCIENCE
卷 37, 期 7, 页码 1835-1852出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3132-16.2017
关键词
anticipatory; associative learning; olfaction; reward; sensory; top-down
资金
- National Institutes of Health/National Institute on Deafness and Other Communication Disorders Grants [R01 DC00566, F32 DC011980, P30 DC04657]
- National Natural Science Foundation of China Grant [NSFC 31571082]
The firing rate of the mitral/tufted cells in the olfactory bulb is known to undergo significant trial-to-trial variability and is affected by anesthesia. Here we ask whether odorant-elicited changes in firing rate depend on the rate before application of the stimulus in the awake and anesthetized mouse. We find that prestimulus firing rate varies widely on a trial-to-trial basis and that the stimulus-induced change in firing rate decreases with increasing prestimulus firing rate. Interestingly, this prestimulus firing rate dependence was different when the behavioral task did not involve detecting the valence of the stimulus. Finally, when the animal was learning to associate the odor with reward, the prestimulus firing rate was smaller for false alarms compared with correct rejections, suggesting that intrinsic activity reflects the anticipatory status of the animal. Thus, in this sensory modality, changes in behavioral status alter the intrinsic prestimulus activity, leading to a change in the responsiveness of the second-order neurons. We speculate that this trial-to-trial variability in odorant responses reflects sampling of the massive parallel input by subsets of mitral cells.
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