期刊
JOURNAL OF NEUROSCIENCE
卷 37, 期 45, 页码 10817-10825出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2569-17.2017
关键词
Alzheimer's disease; arousal; basal ganglia; gamma frequency; of MRI; optogenetics
资金
- NIA NIH HHS [RF1 AG047666] Funding Source: Medline
- NINDS NIH HHS [R01 NS064984, R01 NS087159] Funding Source: Medline
Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of circuit mechanisms underlying pathological motor behavior, arousal regulation, and protein accumulation. Finally, we discuss how optogenetic functional magnetic resonance imaging reveals global scale circuit mechanisms, and how circuit manipulations could lead to new treatments of neurological diseases.
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