4.7 Article

Ultra-High-Field fMRI Reveals a Role for the Subiculum in Scene Perceptual Discrimination

期刊

JOURNAL OF NEUROSCIENCE
卷 37, 期 12, 页码 3150-3159

出版社

SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3225-16.2017

关键词

7 T fMRI; episodic memory; hippocampus; medial temporal lobe; perception; scene processing

资金

  1. Medical Research Council [G1002149]
  2. Wellcome Trust [104943/Z/14/Z]
  3. MRC [G0700399, G1002149, G0900806] Funding Source: UKRI
  4. Medical Research Council [G0900806, G0700399, G1002149] Funding Source: researchfish

向作者/读者索取更多资源

Recent representational accounts suggest a key role for the hippocampus in complex scene perception. Due to limitations in scanner field strength, however, the functional neuroanatomy of hippocampal-dependent scene perception is unknown. Here, we applied 7 T high-resolution functional magnetic resonance imaging (fMRI) alongside a perceptual oddity task, modified from nonhuman primate studies. This task requires subjects to discriminate highly similar scenes, faces, or objects from multiple viewpoints, and has revealed selective impairments during scene discrimination following hippocampal lesions. Region-of-interest analyses identified a preferential response in the subiculum subfield of the hippocampus during scene, but not face or object, discriminations. Notably, this effect was in the anteromedial subiculum and was not modulated by whether scenes were subsequently remembered or forgotten. These results highlight the value of ultra-high-field fMRI in generating more refined, anatomically informed, functional accounts of hippocampal contributions to cognition, and a unique role for the human subiculum in discrimination of complex scenes from different viewpoints.

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