期刊
JOURNAL OF NEUROSCIENCE
卷 37, 期 40, 页码 9675-9685出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1372-17.2017
关键词
avoidance; fear; gamma-oscillations; hippocampus; reconsolidation; theta-oscillations
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)
- CAPES
- Programa de Pos-Graduacao em Psicobiologia at Universidade Federal do Rio Grande do Norte (UFRN, Brazil)
Reactivated memories can be modified during reconsolidation, making this process a potential therapeutic target for posttraumatic stress disorder (PTSD), a mental illness characterized by the recurring avoidance of situations that evoke trauma-related fears. However, avoidance memory reconsolidation depends on a set of still loosely defined boundary conditions, limiting the translational value of basic research. In particular, the involvement of the hippocampus in fear-motivated avoidance memory reconsolidation remains controversial. Combining behavioral and electrophysiological analyses in male Wistar rats, wefound that previous learning of relevant nonaversive information is essential to elicit the participation of the hippocampus in avoidance memory reconsolidation, which is associated with an increase in theta- and gamma-oscillation power and cross-frequency coupling in dorsal CA1 during reactivation of the avoidance response. Our results indicate that the hippocampus is involved in memory reconsolidation only when reactivation results in contradictory representations regarding the consequences of avoidance and suggest that robust nesting of hippocampal theta- gamma rhythms at the time of retrieval is a specific reconsolidation marker.
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