期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 81, 期 1, 页码 66-70出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2014.09.028
关键词
Serogroup 15; Streptococcus pneumoniae; Protein conjugate vaccine
资金
- Wellcome Trust
- Pfizer Limited
- Merck
- Pfizer
- GlaxoSmithKline
- Intercell
Serogroup 15 pneumococcal isolates from nasopharyngeal carriage of hospitalized children admitted to a teaching hospital in Hong Kong from April 2009 to September 2013 were characterized by pulse-field gel electrophoresis (PFGE), multilocus sequence typing, and antimicrobial non-susceptibility testing. The overall proportion of serogroup 15 isolates in the pre-PCV7 and post-PCV13 periods rose from 5.7% to 20.0%. The increase in trend for serotype 15B/C was statistically significant among children presented with pneumonia; bronchiolitis; up-pet respiratory tract infection; and febrile, non-respiratory diseases and for serotype 15A/F, among children with bronchiolitis and febrile, non-respiratory diseases. The predominant PFGE cluster of serotype 15B/C belonged to sequence type (ST) 199. Replacement of this more susceptible cluster (Ery and Tet non-susceptibilities of 32.2% and 25.4%) with the non-susceptible cluster, ST8859 (Ery and Tet non-susceptibilities of 91.7% and 87.5%) was noted. ST63 was the predominant serotype 15A cluster (Ery and Tet non-susceptibilities of 97.4% and 92.3%). Serogroup 15 subtypes have emerged in the post-PCV13 era, and these non-susceptible clusters warrant closer monitoring as candidates for incorporation to future pneumococcal vaccines. (C) 2015 Elsevier Inc. All rights reserved.
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